8-HYDROXYWARFARIN

[ Density]:
1.384g/cm3

[ Boiling Point ]:
519.6ºC at 760mmHg

[ Melting Point ]:
185-187ºC

[ Molecular Formula ]:
C₁₉H₁₆O₅

[ Molecular Weight ]:
324.32700

[ Flash Point ]:
189.3ºC

[ Exact Mass ]:
324.10000

[ PSA ]:
87.74000

[ LogP ]:
3.31520

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.659

Click to get detail MSDS

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R22

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2932209090

Click to get detail synthetic route

Precursor

DownStream

[ HS Code ]: 2932209090

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Investigation of two-dimensional high performance liquid chromatography approaches for reversed phase resolution of warfarin and hydroxywarfarin isomers.

J. Chromatogr. A. 1363 , 200-6, (2014)

Several offline and online 2D HPLC methods were investigated for the reversed phase resolution of a complex mixture of closely related warfarin and hydroxywarfarin isomers. By combining reversed phase...

Hydroxywarfarin metabolites potently inhibit CYP2C9 metabolism of S-warfarin.

Chem. Res. Toxicol. 23(5) , 939-45, (2010)

Coumadin (R/S-warfarin) anticoagulant therapy poses a risk to over 50 million Americans, in part due to interpersonal variation in drug metabolism. Consequently, it is important to understand how meta...

Metabolism of R- and S-warfarin by CYP2C19 into four hydroxywarfarins.

Drug Metab. Lett. 6(3) , 157-64, (2012)

Coumadin (R/S-warfarin) is a highly efficacious and widely used anticoagulant; however, its highly variable metabolism remains an important contributor to uncertainties in therapeutic responses. Pharm...

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