β-catenin-IN-37
Names
[ CAS No. ]:
1783856-40-5
[ Name ]:
β-catenin-IN-37
Biological Activity
[Description]:
β-catenin-IN-37 is a novel potent, and selective small-molecule inhibitor for the β-catenin/Tcf4 protein-protein interaction with Ki of 17 uM; suppresses canonical Wnt signaling, downregulates the expression of Wnt target genes; inhibits the growth of Wnt-activated cancer cells with the IC50 values of 26 uM and 31 uM for SW480 and HCT116 cells, respectively.
[References]
References 1. Catrow JL, et al. J Med Chem. 2015 Jun 11;58(11):4678-92. View Related Products by Target Beta-catenin
Chemical & Physical Properties
[ Molecular Formula ]:
C13H9N9O
[ Molecular Weight ]:
307.277