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Azide-PEG3-Tos

Names

[ CAS No. ]:
178685-33-1

[ Name ]:
Azide-PEG3-Tos

[Synonym ]:
2-(2-(2-azidoethoxy)ethoxy)ethyl toluenesulfonate
toluene 4-sulfonic acid 2-[2-(2-azidoethoxy)ethoxy] ethyl ester
2-[2-(2-azidoethoxy)ethoxy]ethyl 4-methylbenzenesulfonate
2-(2-(2-azidoethoxy)ethoxy)ethyl tosylate
α-azidodeoxy-ω-O-tosyltriethyleneglycol
2-(2-(2-azidoethoxy)ethoxy)ethyl 4-methylbenzenesulfonate
Toluene-4-sulfonic acid 2-[2-(2-azido-ethoxy)-ethoxy]-ethyl ester

Biological Activity

[Description]:

Azide-PEG3-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azide-PEG3-Tos is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Non-cleavable


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].

[References]

[1]. Borchmann DE, et al. GRGDS-Functionalized Poly(lactide)-graft-poly(ethylene glycol) Copolymers: Combining Thiol-Ene Chemistry with Staudinger Ligation. Macromolecules. 2013 Jun 11;46(11):4426-4431.

[2]. Park, Tae Kyo, et al. Compound bearing beta-galactoside-introduced self-immolative linker. WO2018124758A2.

Chemical & Physical Properties

[ Molecular Formula ]:
C13H19N3O5S

[ Molecular Weight ]:
329.37200

[ Exact Mass ]:
329.10500

[ PSA ]:
119.96000

[ LogP ]:
2.57736

Related Compounds