Lutikizumab

Names

[ Name ]:
Lutikizumab

Biological Activity

[Description]:

Lutikizumab (ABT-981) is an anti-IL-1α and IL-1β dual variable domain immunoglobulin. Lutikizumab binds and inhibits IL-1α and IL-1β. Lutikizumab can be used for the research of osteoarthritis[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Interleukin Related

Research Areas >> Inflammation/Immunology

[In Vitro]

ABT-981 可同时结合人 IL-α 和 IL-1β 分子[1]。 ABT-981 对 IL-α 和 IL-1β 表现出高度特异性的结合作用相比于其他 IL-1 家族成员[1]。

[In Vivo]

Lutikizumab (0.0001-1 mg/kg，腹腔注射，1 次) 对 IL-1α 和 IL-1β 诱导的 IL-6 产生有效抑制作用[1]。 Animal Model: Female C57/BL6 mice with IL-1α and IL-1β injection[1] Dosage: 0.0001-1 mg/kg Administration: Intraperitoneal injection, 0.0001-1 mg/kg, once Result: Dose-dependently decreased the murine IL-6 generated by human and cynomolgus IL-1α and IL-1β.

[References]

[1]. Lacy SE, et al. Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig(TM)) molecule that specifically and potently neutralizes both IL-1α and IL-1β. MAbs. 2015;7(3):605-19.

Chemical & Physical Properties

No Any Chemical & Physical Properties