N-(4-((6,7-DIMETHOXY-4-QUINAZOLINYL)AMIN

Names

[ CAS No. ]:
179247-42-8

[ Name ]:
N-(4-((6,7-DIMETHOXY-4-QUINAZOLINYL)AMIN

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₁ClN₄O₃

[ Molecular Weight ]:
436.89100

[ Exact Mass ]:
436.13000

[ PSA ]:
85.37000

[ LogP ]:
5.59090

MSDS

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Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R22

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

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Articles

SAR and inhibitor complex structure determination of a novel class of potent and specific Aurora kinase inhibitors.

Bioorg. Med. Chem. Lett. 16 , 1320-1323, (2006)

A novel series of 5-aminopyrimidinyl quinazolines has been developed from anilino-quinazoline 1, which was identified in a high throughput screen for Aurora A. Introduction of the pyrimidine ring and ...