LFS-1107

Names

[ CAS No. ]:
1799330-91-8

[ Name ]:
LFS-1107

Biological Activity

[Description]:

LFS-1107 is a reversible CRM1 inhibitor (Kd: 12.5 pM). LFS-1107 can selectively eliminate extranodal natural killer/T cell lymphoma (ENKTL) cells and can be used for cancer research[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Apoptosis >> Survivin
Signaling Pathways >> Membrane Transporter/Ion Channel >> CRM1
Signaling Pathways >> Apoptosis >> c-Myc
Signaling Pathways >> Immunology/Inflammation >> COX

[Target]

COX-2


[References]

[1]. He Liu, et al. Discovery and biological evaluation of a potent small molecule CRM1 inhibitor for its selective ablation of extranodal NK/T cell lymphoma eLife 12:e80625.

Chemical & Physical Properties

[ Molecular Formula ]:
C12H11N5OS2

[ Molecular Weight ]:
305.38

Related Compounds