PSB-12431

Names

[ Name ]:
PSB-12431

Biological Activity

[Description]:

PSB-12431 is an α,β-Methylene-ADP (AOPCP) derivative, potent, selective ecto-5′-Nucleotidase (eN, CD73) inhibitor with Ki of 9.2 nM for rat recombinant eN; displays high selectivity versus other ecto-nucleotidases and ADP-activated P2Y receptors, has high metabolic stability.

[References]

References 1. Bhattarai S, et al. J Med Chem. 2015 Aug 13;58(15):6248-63. View Related Products by Target Other Targets

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₂₂N₄O₁₀P₂

[ Molecular Weight ]:
516.34

Related Compounds

PSB-1584
PSB-12553
PSB 603
PSB 06126
PSB 0739
PSB CB5
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
2-Methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-pyridin-2-ylpropanoic acid
(4-Methyl-tetrahydro-furan-2-yl)-methanol
Methyl 5-(oxolan-2-yl)pyrrolidine-2-carboxylate
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine