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17β-Estradiol 17β-D-Glucuronide

Names

[ CAS No. ]:
1806-98-0

[ Name ]:
17β-Estradiol 17β-D-Glucuronide

[Synonym ]:
17β-Estradiol 17β-D-Glucuronide
[14C]-Estradiol 17beta-glucuronide
17beta-estradiol 17-glucosiduronic acid
1,3,5(10)-ESTRATRIEN-17ALPHA-ETHYNYL-3,17BETA-DIOL-17BETA-GLUCURONIDE
17Beta-Estradiol 17Beta-D-Glucuronide

Biological Activity

[Description]:

Estradiol 17-(β-D-Glucuronide), a metabolite of estrogen, is well known to cause intrahepatic cholestasis in humans. Estradiol 17-(β-D-Glucuronide) is a high-affinity substrate for oatp organic anion transporter[1].

[Related Catalog]:

Research Areas >> Endocrinology
Research Areas >> Metabolic Disease

[References]

[1]. Kinbara S, et al. Improvement of estradiol-17 beta-D-glucuronide-induced cholestasis by sodium tauroursodeoxycholate therapy in rats. Scand J Gastroenterol. 1997;32(9):947-952.  

[2]. Kanai N,et al. Estradiol 17 beta-D-glucuronide is a high-affinity substrate for oatp organic anion transporter. Am J Physiol. 1996 Feb;270(2 Pt 2):F326-31.  

Chemical & Physical Properties

[ Molecular Formula ]:
C24H32O8

[ Molecular Weight ]:
448.51

[ Exact Mass ]:
448.21000

[ PSA ]:
136.68000

[ LogP ]:
1.52570

[ Vapour Pressure ]:
2.34E-20mmHg at 25°C

Precursor & DownStream

Precursor

DownStream

Related Compounds