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INDINAVIR (100 MG)F0D3080.971MG/MG(AI)

Names

[ CAS No. ]:
180683-37-8

[ Name ]:
INDINAVIR (100 MG)F0D3080.971MG/MG(AI)

[Synonym ]:
(2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-oxopentyl]-N-tert-butyl-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide,hydrate

Chemical & Physical Properties

[ Boiling Point ]:
877.9ºC at 760 mmHg

[ Melting Point ]:
158 °C

[ Molecular Formula ]:
C36H49N5O5

[ Molecular Weight ]:
631.80500

[ Flash Point ]:
484.7ºC

[ Exact Mass ]:
631.37300

[ PSA ]:
134.24000

[ LogP ]:
4.35900

[ Vapour Pressure ]:
5.56E-33mmHg at 25°C

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

Articles

Novel protease inhibitor-loaded Nanoparticle-in-Microparticle Delivery System leads to a dramatic improvement of the oral pharmacokinetics in dogs.

Biomaterials 37 , 383-94, (2015)

With the advent of the Highly Active Antiretroviral Therapy, the morbidity and the mortality associated to HIV have been considerably reduced. However, 35-40 million people bear the infection worldwid...

Blood-brain barrier pharmacoproteomics-based reconstruction of the in vivo brain distribution of P-glycoprotein substrates in cynomolgus monkeys.

J. Pharmacol. Exp. Ther. 350(3) , 578-88, (2014)

The aim of this study was to investigate whether in vivo drug distribution in brain in monkeys can be reconstructed by integrating four factors: protein expression levels of P-glycoprotein (P-gp)/mult...

Drug susceptibility to etravirine and darunavir among Human Immunodeficiency Virus Type 1-derived pseudoviruses in treatment-experienced patients with HIV/AIDS in South Korea.

Virol. J. 12(1) , 53, (2015)

In South Korea, about 20 types of antiretroviral drugs are used in the treatment of patients with human immunodeficiency virus/acquired immune deficiency syndrome. Since 2010, raltegravir, etravirine,...


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