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Methylamino-PEG1-Boc

Names

[ CAS No. ]:
1807521-03-4

[ Name ]:
Methylamino-PEG1-Boc

[Synonym ]:
Propanoic acid, 3-[2-(methylamino)ethoxy]-, 1,1-dimethylethyl ester
MFCD28155197
2-Methyl-2-propanyl 3-[2-(methylamino)ethoxy]propanoate

Biological Activity

[Description]:

Methylamino-PEG1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
266.7±15.0 °C at 760 mmHg

[ Molecular Formula ]:
C10H21NO3

[ Molecular Weight ]:
203.279

[ Flash Point ]:
115.1±20.4 °C

[ Exact Mass ]:
203.152145

[ LogP ]:
1.15

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.436

Related Compounds