Poloxin-2

Names

[ Name ]:
Poloxin-2

Biological Activity

[Description]:

A potent, selective PLK1 PBD inhibitor with IC50 of 1.36 uM; shows >10-fold selectivity over Plk2 PBD and Plk3 PBD; significantly improved potency and selectivity over Poloxin; induces mitotic arrest and apoptosis in cultured human tumor cells at low micromolar concentrations.

[References]

References 1. Scharow A, et al. ACS Chem Biol. 2015 Nov 20;10(11):2570-9. 2. Scharow A, et al. Chembiochem. 2016 Apr 15;17(8):759-67. View Related Products by Target Polo-like Kinase (PLK)

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₅NO₃

[ Molecular Weight ]:
269.3

Related Compounds

Poloxin
(1,2-dimethylpyrrolidin-2-yl)methanol
N-[2-[3,4,5,6,7,8-Hexahydroazocin-1(2H)-yl]ethyl]phenylethylmalonamidic acid ethyl ester
3-(2-carboxy-5-chlorophenyl)-4-fluorobenzoic acid
Benzaldehyde,2,3,4,5,6-pentachloro-
3-(2-carboxy-5-fluorophenyl)-4-fluorobenzoic acid
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
(S)-1-Cyclopropyl-4-methylpent-1-yn-3-amine hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
(9H-fluoren-9-yl)methyl N-{2-[(4-hydroxypiperidin-1-yl)methyl]phenyl}carbamate
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine