SMAP
Names
[ CAS No. ]:
1809427-18-6
[ Name ]:
SMAP
Biological Activity
[Description]:
SMAP (DT-061, DT061) is an orally bioavailable small molecule activator of PP2A, inhibits KRAS-driven tumor growth; acts by binding to the PP2A Aα scaffold subunit to drive conformational changes in PP2A; inhibits the growth of KRAS-mutant lung cancers in mouse xenografts and transgenic models.
[References]
References 1. Sangodkar J, et al. J Clin Invest. 2017 Jun 1;127(6):2081-2090. 2. Kauko O, et al. Sci Transl Med. 2018 Jul 18;10(450). pii: eaaq1093. View Related Products by Target Protein Phosphatase/PTP
Chemical & Physical Properties
[ Molecular Formula ]:
C25H23F3N2O5S
[ Molecular Weight ]:
520.523