MNKI-85
Names
[ CAS No. ]:
1812885-57-6
[ Name ]:
MNKI-85
Biological Activity
[Description]:
MNKI-85 is a potent and selective Mnk2 inhibitor with Ki of 31 nM, displays no inhibitory activities against Mnk1, CDK2A, CDK9T, and CDK4D; effectively inhibits the growth of AML cells that possess an M5 subtype with FLT3-internal tandem duplication mutation, a powerful pharmacologic tool in studying the Mnk2/eIF4E-mediated tumorigenic mechanism.
[References]
References 1. Teo T, et al. Mol Pharmacol. 2015 Aug;88(2):380-9. View Related Products by Target MNK
Chemical & Physical Properties
[ Molecular Formula ]:
C20H23FN4O3S
[ Molecular Weight ]:
418.487