tert-Butyl 4-aminobenzoate

Names

[ Name ]:
tert-Butyl 4-aminobenzoate

[Synonym ]:
tert-Butyl p-aminobenzoate
4-amino-benzoic acid t-butyl ester
tert-Butyl 4-aminobenzoate
tert-Butyl4-aminobenzoate
2-Methyl-2-propanyl 4-aminobenzoate
tert-Butyl-4-aminobenzolcarboxylat
4-Aminobenzoic Acid tert-Butyl Ester
Benzoic acid, 4-amino-, 1,1-dimethylethyl ester
MFCD00665790
tert-Butyl-4-aminobenzoate

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
322.4±15.0 °C at 760 mmHg

[ Melting Point ]:
108-110 °C

[ Molecular Formula ]:
C₁₁H₁₅NO₂

[ Molecular Weight ]:
193.242

[ Flash Point ]:
173.6±17.9 °C

[ Exact Mass ]:
193.110275

[ PSA ]:
52.32000

[ LogP ]:
2.64

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.539

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2922499990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

Quinazoline antifolates thymidylate synthase inhibitors: lipophilic analogues with modification to the C2-methyl substituent.

J. Med. Chem. 39 , 695, (1996)

Modification of the potent thymidylate synthase (TS) inhibitor 1-[[N-[4-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N- prop-2-ynylamino]benzoyl]amino]methyl]-3-nitrobenzene (4a) has led to ...

G.M.F. Visset et al.

J. Med. Chem. 35 , 659, (1992)