LUF7346

Names

[ Name ]:
LUF7346

[Synonym ]:
LUF7346
Acetamide, 2-[4-(2-bromobenzoyl)phenoxy]-N-3-pyridinyl-
2-[4-(2-BROMOBENZOYL)PHENOXY]-N-(PYRIDIN-3-YL)ACETAMIDE
2-[4-(2-Bromobenzoyl)phenoxy]-N-(3-pyridinyl)acetamide

Biological Activity

[Description]:

LUF7346 is a novel hERG allosteric modulator that slows IKr deactivation and positively shifting IKr inactivation; rescues the genetic form of LQTS, reverses drug-induced LQTS and correct thes combination of genetic and drug-induced LQTS; normalises both action- and field potentials (AP and FP, respectively) in all hPSC-CMs by slowing IKr deactivation and positively shifting the IKr inactivation.

[References]

References 1. Sala L, et al. EMBO Mol Med. 2016 Sep 1;8(9):1065-81. 2. Yu Z, et al. Eur J Med Chem. 2015 Dec 1;106:50-9. 3. Yu Z, et al. Circ Arrhythm Electrophysiol. 2016 Apr;9(4):e003439. View Related Products by Target Potassium Channel

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
632.5±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₁₅BrN₂O₃

[ Molecular Weight ]:
411.249

[ Flash Point ]:
336.3±30.1 °C

[ Exact Mass ]:
410.026611

[ LogP ]:
3.35

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.656