fluorophenothiazine dihydrochloride

Names

[ CAS No. ]:
1827-91-4

[ Name ]:
fluorophenothiazine dihydrochloride

[Synonym ]:
Piclopastine

Chemical & Physical Properties

[ Density]:
1.256g/cm3

[ Boiling Point ]:
600.4ºC at 760 mmHg

[ Molecular Formula ]:
C₂₄H₃₁ClF₃N₃O₂S

[ Molecular Weight ]:
518.03500

[ Flash Point ]:
316.9ºC

[ Exact Mass ]:
517.17800

[ PSA ]:
64.48000

[ LogP ]:
5.06750

[ Vapour Pressure ]:
2.9E-15mmHg at 25°C

[ Index of Refraction ]:
1.567

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KM5425000

CHEMICAL NAME :: Ethanol, 2-(2-(4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)pro pyl)-1-piperazinyl)et hoxy)-, dihydrochloride

CAS REGISTRY NUMBER :: 1827-91-4

LAST UPDATED :: 199506

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C24-H30-F3-N3-O2-S.2Cl-H

MOLECULAR WEIGHT :: 554.55

WISWESSER LINE NOTATION :: T C666 BN ISJ EXFFF B3- AT6N DNTJ D2O2Q &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 588 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - chromodacryorrhea Sense Organs and Special Senses (Eye) - ptosis Behavioral - rigidity (including catalepsy)

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 136,476,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 199 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - chromodacryorrhea Sense Organs and Special Senses (Eye) - ptosis Behavioral - rigidity (including catalepsy)

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 136,476,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 136,476,1962