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GLS1 Inhibitor

Names

[ CAS No. ]:
1832646-52-2

[ Name ]:
GLS1 Inhibitor

Biological Activity

[Description]:

GLS1 inhibitor is an inhibitor of glutaminase 1

[In Vitro]

GLS1 inhibitor is an inhibitor of glutaminase 1 (GLS1; IC50 = 0.021 μM).1 It inhibits the growth of NCI H1703 non-small cell lung cancer (NSCLC) cells in vitro (GI50 = 0.011 μM). GLS1 inhibitor (100 mg/kg) reduces tumor growth, increases tumor levels of glutamine, and decreases tumor levels of glutamate and aspartate in an NCI H1703 mouse xenograft model.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H21N7O2S

[ Molecular Weight ]:
411.5


Related Compounds