GLS1 Inhibitor
Names
[ CAS No. ]:
1832646-52-2
[ Name ]:
GLS1 Inhibitor
Biological Activity
[Description]:
GLS1 inhibitor is an inhibitor of glutaminase 1
[In Vitro]
GLS1 inhibitor is an inhibitor of glutaminase 1 (GLS1; IC50 = 0.021 μM).1 It inhibits the growth of NCI H1703 non-small cell lung cancer (NSCLC) cells in vitro (GI50 = 0.011 μM). GLS1 inhibitor (100 mg/kg) reduces tumor growth, increases tumor levels of glutamine, and decreases tumor levels of glutamate and aspartate in an NCI H1703 mouse xenograft model.
Chemical & Physical Properties
[ Molecular Formula ]:
C19H21N7O2S
[ Molecular Weight ]:
411.5