L778123 dihydrochloride

Names

[ Name ]:
L778123 dihydrochloride

Biological Activity

[Description]:

L-778123 is an inhibitor of FPTase and GGPTase-I, which was developed in part because it can completely inhibit Ki-Ras prenylation. The combination of L-778,123 and radiotherapy at dose level 1 showed acceptable toxicity in patients with locally advanced pancreatic cancer. Radiosensitization of a patient-derived pancreatic cancer cell line was observed.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₂Cl₃N₅O

[ Molecular Weight ]:
478.802

Related Compounds

Quinpirole dihydrochloride
Benzylhydrazine dihydrochloride
Gosogliptin dihydrochloride
preQ1 Dihydrochloride
Furosine dihydrochloride
ethyl (2R)-2-[2-[[(2R)-1-ethoxy-1-oxo-3-sulfanylpropan-2-yl]amino]ethylamino]-3-sulfanylpropanoate,dihydrochloride
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
5-chloro-N-(2,6-difluorobenzyl)-6-((tetrahydrofuran-3-yl)oxy)nicotinamide
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(2-chloro-6-cyclopropylphenyl)(3-iodo-1H-pyrazolo[4,3-b]pyridin-1-yl)methanone
(4-Methyl-tetrahydro-furan-2-yl)-methanol
Naphthalen-1-yl(7-(o-tolyl)-1,4-thiazepan-4-yl)methanone
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde