CXCR2-IN-68

CXCR2-IN-68 is a potent, selective, brain penetrant, and orally bioavailable CXCR2 antagonist with pIC50 of 9.0, displays 730-fold selectivity over CXCR1 and >1,900-fold selectivity over all other chemokine receptors; inhibits human whole blood Gro-α induced CD11b expression with IC50 of 0.04 µM, 17-fold more potent than Navarixin; significantly inhibits neutrophil infiltration in mouse at 1, 3, 10 mg/kg oral dosing twice daily (BID).

References 1. Lu H, et al. J Med Chem. 2018 Feb 28. doi: 10.1021/acs.jmedchem.7b01854. View Related Products by Target Chemokine Receptor (CCR and CXCR)