BNM-III-170
Names
[ CAS No. ]:
1859189-54-0
[ Name ]:
BNM-III-170
Biological Activity
[Description]:
BNM-III-170 is a small-molecule CD4-mimetic compound that enhances vaccine efficacy against HIV-1 challenge in vivo; binds the HIV-1 gp120 Env and promotes conformational changes similar to those induced by CD4, exposing conserved Env elements to antibodies; synergizes with antibodies elicited by monomeric HIV-1 gp120 to protect monkeys from multiple high-dose intrarectal challenges with a heterologous simian-human immunodeficiency virus (SHIV).
[References]
References 1. Madani N, et al. Nat Commun. 2018 Jun 18;9(1):2363. View Related Products by Target HIV
Chemical & Physical Properties
[ Molecular Formula ]:
C21H24ClFN6O2
[ Molecular Weight ]:
446.911