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BNM-III-170 trifluoroacetate

Names

[ CAS No. ]:
1859189-55-1

[ Name ]:
BNM-III-170 trifluoroacetate

Biological Activity

[Description]:

BNM-III-170 TFA salt is a small-molecule CD4-mimetic compound that enhances vaccine efficacy against HIV-1 challenge in vivo; binds the HIV-1 gp120 Env and promotes conformational changes similar to those induced by CD4, exposing conserved Env elements to antibodies; synergizes with antibodies elicited by monomeric HIV-1 gp120 to protect monkeys from multiple high-dose intrarectal challenges with a heterologous simian-human immunodeficiency virus (SHIV).

[References]

References 1. Madani N, et al. Nat Commun. 2018 Jun 18;9(1):2363. View Related Products by Target HIV

Chemical & Physical Properties

[ Molecular Formula ]:
C25H26ClF7N6O6

[ Molecular Weight ]:
674.958


Related Compounds