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SirReal1-O-propargyl

Names

[ CAS No. ]:
1862237-99-7

[ Name ]:
SirReal1-O-propargyl

Biological Activity

[Description]:

PROTAC Sirt2-binding moiety 1 is a selective and highly potent Sirtuin 2 (Sirt2) inhibitor, with an IC50 of 2.4 μM. For the development of sirtuin rearranging ligands (SirReals)-based PROTAC[1].

[Related Catalog]:

Research Areas >> Others

[Target]

IC50: 2.4 μM (Sirt2)[1].


[References]

[1]. Schiedel M, et al. Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals). J Med Chem. 2018 Jan 25;61(2):482-491.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H20N4O2S2

[ Molecular Weight ]:
424.54

[ Storage condition ]:
2-8℃

Related Compounds