MZ-242

Names

[ Name ]:
MZ-242

Biological Activity

[Description]:

A novel potent, selective Sirt2 inhibitor with IC50 of 0.118 uM; displays no inhibitory activity against Sirt1 and Sirt 3 (IC50>100 uM).

[References]

References 1. Szabó A, et al. Sci Rep. 2017 Dec 6;7(1):17070. 2. Schiedel M, et al. Angew Chem Int Ed Engl. 2016 Feb 5;55(6):2252-6. View Related Products by Target Sirtuin

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₂₇N₇O₃S₂

[ Molecular Weight ]:
525.646

Related Compounds

3-[(E)-(6-methyl-4-oxo-2-piperidin-1-ylpyrido[1,2-a]pyrimidin-3-yl)methylideneamino]-1,3-oxazolidin-2-one
methyl sulfate,propan-2-yl 1,6-dimethyl-4-oxo-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-1-ium-3-carboxylate
3-[(E)-(6-methyl-4-oxo-2-piperidin-1-yl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-3-yl)methylideneamino]-1,3-oxazolidin-2-one
butyl 1,6-dimethyl-4-oxo-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-1-ium-3-carboxylate,methyl sulfate
[10-hydroxy-5-(10-hydroxy-7,9-dimethoxy-3-methyl-3,4-dihydro-1H-benzo[g]isochromen-5-yl)-7,9-dimethoxy-3-methyl-3,4-dihydro-1H-benzo[g]isochromen-4-yl] acetate
5-chloro-2-[2-[(5-chloro-3-ethyl-3H-benzothiazol-2-ylidene)methyl]but-1-enyl]-3-(3-sulphonatobutyl)benzothiazolium
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
1-Ethyl-4-fluoro-2-methylbenzene
2-methyl-3-(6-oxo-3-(thiophen-2-yl)pyridazin-1(6H)-yl)-N-(2-(trifluoromethoxy)benzyl)propanamide
(4-Methyl-tetrahydro-furan-2-yl)-methanol
2-(1H-pyrazol-1-ylmethyl)benzoic acid hydrochloride
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde