Cortistatin 14

Names

[ Name ]:
Cortistatin 14

[Synonym ]:
cortistatin14
Cortistatin 14

Biological Activity

[Description]:

Cortistatin-14, a neuropeptide have structural similarity to somatostatin-14, binds and exerts its function via the somatostatin receptors (sst1-sst5). Cortistatin-14 shows anticonvulsive, neuroprotective effect and remarkable anti-inflammatory properties[1][2][3][4].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Somatostatin Receptor

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

[References]

[1]. De Lecea L, et al. A cortical neuropeptide with neuronal depressant and sleep-modulating properties. Nature. 1996 May 16;381(6579):242-5.

[2]. Baranowska B, et al. Cortistatin and pituitary hormone secretion in rat. J Physiol Pharmacol. 2009 Mar;60(1):151-6.

[3]. Braun H, et al. Protective effects of cortistatin (CST-14) against kainate-induced neurotoxicity in rat brain. Brain Res. 1998 Aug 24;803(1-2):54-60.

[4]. Markovics A, et al. Comparison of the anti-inflammatory and anti-nociceptive effects of cortistatin-14 and somatostatin-14 in distinct in vitro and in vivo model systems. J Mol Neurosci. 2012 Jan;46(1):40-50.

Chemical & Physical Properties

[ Molecular Formula ]:
C₈₁H₁₁₄N₂₀O₁₈S₂

[ Molecular Weight ]:
1721.01000

[ Exact Mass ]:
1719.79000

[ PSA ]:
675.86000

[ LogP ]:
3.12890

[ Storage condition ]:
−20°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

The cortical neuropeptide, cortistatin-14, impairs post-training memory processing.

Brain Res. 775 , 250-252, (1997)

Cortistatin-14, a neuropeptide, is present primarily in the cortex and hippocampus. In the hippocampus, cortistatin-14 inhibits pyramidal cell firing and co-exists with GABA. To determine if cortistat...

Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions.

Brain Res. Brain Res. Rev. 33 , 228-241, (2000)

Cortistatin is a recently discovered neuropeptide relative of somatostatin named after its predominantly cortical expression and ability to depress cortical activity. Cortistatin-14 shares 11 of the 1...

Structural and compositional determinants of cortistatin activity.

J. Neurosci. 56 , 611-619, (1999)

Cortistatin-14 (CST-14) is a putative novel neuropeptide that shares 11 of its 14 residues with somatostatin-14 (SRIF-14), yet its effects on sleep physiology, locomotor behavior and hippocampal funct...