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BMS-770767

Names

[ CAS No. ]:
1875067-34-7

[ Name ]:
BMS-770767

[Synonym ]:
(1s,4s)-4-[8-(2-Chlorophenoxy)[1,2,4]triazolo[4,3-a]pyridin-3-yl]bicyclo[2.2.1]heptan-1-ol
Bicyclo[2.2.1]heptan-1-ol, 4-[8-(2-chlorophenoxy)-1,2,4-triazolo[4,3-a]pyridin-3-yl]-
4-[8-(2-Chlorophenoxy)-1,2,4-triazolo[4,3-a]pyridin-3-yl]-bicyclo[2.2.1]heptan-1-ol
BMS-770767

Biological Activity

[Description]:

BMS-770767 is an 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitor in type 2 diabetes. 11β-HSD1 is an important enzyme that is widely expressed in liver, adipose tissue and other tissues and plays an important role in metabolic diseases such as diabetes and obesity[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

[References]

[1]. Brad D Maxwell, et al. The synthesis and analysis of [phenyl-14 C(U)]BMS-770767 and [13 C6 ]BMS-770767 for use in discovery biotransformation, human ADME and bioanalytical studies. J Labelled Comp Radiopharm. 2016 Dec;59(14):657-664.   

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C19H18ClN3O2

[ Molecular Weight ]:
355.82

[ Exact Mass ]:
355.108765

[ LogP ]:
3.45

[ Index of Refraction ]:
1.726

Related Compounds