JK-273
Names
[ CAS No. ]:
187723-38-2
[ Name ]:
JK-273
[Synonym ]:
6-(4-Aminophenyl)-N-(3-chlorophenyl)-1H-pyrrolo[2,3-d]pyrimidin-4-amine
7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 6-(4-aminophenyl)-N-(3-chlorophenyl)-
Biological Activity
[Description]:
A small molecule inhibitor of α4 integrin-dependent cell migration (IC50=0.5 uM, on the motility of Jurkat T cells) that functions by interacting with γ-parvin; inhibits α4 integrin signaling, shows a selective cytotoxic effect against HCI-H460 NSCLC cells with IC50 of 0.98 uM, less sensitivity to fibroblasts (30-fold selectivity), causes cell cycle arrest at S phase and induces apoptosis.
[References]
References 1. Lee J, et al. Bioorg Med Chem. 2009 Feb 1;17(3):977-80. 2. Lu TN, et al. Biochem Biophys Res Commun. 2017 Sep 16;491(2):355-360. View Related Products by Target Integrin
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Molecular Formula ]:
C18H14ClN5
[ Molecular Weight ]:
335.790
[ Exact Mass ]:
335.093781
[ LogP ]:
4.70
[ Index of Refraction ]:
1.777