AI-10-104

AI-10-104 is a small molecule inhibitor that interferes with CBFβ binding to RUNX proteins with IC50 of 1.25 uM in FRET assays; reduces RUNX transcriptional activity by interfering with the formation of the CBFβ/RUNX1 and/or CBFβ/RUNX3 heterodimers in T-ALL cells; impairs the growth of human T-ALL cell lines and primary patient samples (GI50=2.4 uM).

References 1. Choi A, et al. Blood. 2017 Oct 12;130(15):1722-1733. 2. Illendula A, et al. EBioMedicine. 2016 Jun;8:117-31. View Related Products by Target RUNX1-CBFβ