FFN 206 dihydrochloride
Names
[ CAS No. ]:
1883548-88-6
[ Name ]:
FFN 206 dihydrochloride
[Synonym ]:
4-(2-Aminoethyl)-7-(methylamino)-2H-chromen-2-one dihydrochloride
2H-1-Benzopyran-2-one, 4-(2-aminoethyl)-7-(methylamino)-, hydrochloride (1:2)
Biological Activity
[Description]:
FFN-206 is an excellent VMAT2 (vesicular monoamine transporter 2) substrate capable of detecting VMAT2 activity in intact cells using fluorescence microscopy, with subcellular localization to VMAT2-expressing acidic compartments without apparent labeling of other organelles; the apparent Km of FFN206 at VMAT2 was found to be 1.16±0.10 uM, similar to that of dopamine; an useful tool for optical examination of VMAT2 function in cell culture.
[References]
References 1. Hu G, et al. ACS Chem Biol. 2013 Sep 20;8(9):1947-54. View Related Products by Target Monoamine Transporter
Chemical & Physical Properties
[ Molecular Formula ]:
C12H16Cl2N2O2
[ Molecular Weight ]:
291.174
[ Exact Mass ]:
290.058868