LE-540

A potent, selective RARβ antagonist that inhibits RA-induced transcriptional activation of RARβ, but not RARα, RARγ or RXRα on a variety of RA response elements; inhibits ATRA-induced apoptosis in ZR-75-1 human breast cancer cells; strongly represses 12-O-tetradecanoylphorbol-13-acetate-induced AP-1 activity in the presence of RARβ and RARα.

References 1. Li Y, et al. J Biol Chem. 1999 May 28;274(22):15360-6. 2. Kitaoka K, et al. Brain Res. 2011 Nov 14;1423:10-6. 3. Umemiya H, et al. J Med Chem. 1997 Dec 19;40(26):4222-34. View Related Products by Target RAR/RXR