4,4'-(1-acetyl-2-oxoindolin-3-ylidene)diphenyl di(acetate)
Names
[ CAS No. ]:
18869-73-3
[ Name ]:
4,4'-(1-acetyl-2-oxoindolin-3-ylidene)diphenyl di(acetate)
[Synonym ]:
Laxagen
Phenisatin
Isatex
Laxagetten
EINECS 242-638-4
3,3-bis-(4-acetoxy-phenyl)-1-acetyl-indolin-2-one
Triacetyldiphenolisatin
Neo-Hollaxans
4,4'-(1-acetyl-2-oxoindolin-3-ylidene)diphenyl di(acetate)
Trialax
Dissilax-Zaepfchen
Trisatin
Chemical & Physical Properties
[ Density]:
1.306g/cm3
[ Boiling Point ]:
623.6ºC at 760 mmHg
[ Molecular Formula ]:
C26H21NO6
[ Molecular Weight ]:
443.44800
[ Flash Point ]:
331ºC
[ Exact Mass ]:
443.13700
[ PSA ]:
89.98000
[ LogP ]:
3.82970
[ Vapour Pressure ]:
1.79E-15mmHg at 25°C
[ Index of Refraction ]:
1.613
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- NM3250000
- CHEMICAL NAME :
- 2H-Indol-2-one, 1,3-dihydro-1-acetyl-3,3-bis(4-(acetyloxy)phenyl)-
- CAS REGISTRY NUMBER :
- 18869-73-3
- BEILSTEIN REFERENCE NO. :
- 0365442
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C26-H21-N-O6
- MOLECULAR WEIGHT :
- 443.48
- WISWESSER LINE NOTATION :
- T56 BNV DHJ BV1 DR DOV1& DOV1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 42,468,1953
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 350 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 42,468,1953 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 90 mg/kg/30D-C
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
- REFERENCE :
- JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 42,468,1953
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 5460 mg/kg/1Y-C
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 42,468,1953
Safety Information
[ HS Code ]:
2933790090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933790090
[ Summary ]:
2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%