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AP-1/NF-κB activation inhibitor 1

Names

[ CAS No. ]:
188936-12-1

[ Name ]:
AP-1/NF-κB activation inhibitor 1

Biological Activity

[Description]:

AP-1/NF-κB activation inhibitor 1 is a potent AP-1 and NF-κB mediated transcriptional activation inhibitor (IC50=1 μM), without blocking basal transcription driven by the β-actin promoter. AP-1/NF-κB activation inhibitor 1 has a similar inhibitory effect on the production of IL-2 and IL-8 levels in stimulated cells[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[References]

[1]. Palanki MS, et al. Novel inhibitors of AP-1 and NF-kappaB mediated gene expression: structure-activity relationship studies of ethyl 4-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-2-(trifluoromethyl)++ +pyrimidi ne-5-carboxylate. Bioorg Med Chem Lett. 2000;10(15):1645-1648.

Chemical & Physical Properties

[ Molecular Formula ]:
C13H11F3N4O4

[ Molecular Weight ]:
344.25

Related Compounds