SLV peptide

A tripeptide representing the Fas-C terminus that specifically blocks the interaction of Fap1 with Fas; increases apoptosis sensitivity and decreases β-catenin in vitro, also decrease interaction of Fap1 with Apc, does not alter expression of Fap1 or Apc proteins; induces Fas-mediated apoptosis in a colon cancer cell line that expresses both Fas and FAP-1.

References 1. Huang W, et al. Leukemia. 2016 Jul;30(7):1502-9. 2. Huang W, et al. J Biol Chem. 2013 May 3;288(18):12766-76. 3. Yanagisawa J, et al. J Biol Chem. 1997 Mar 28;272(13):8539-45. 4. Huang W, et al. Leuk Lymphoma. 2013 Mar;54(3):619-30. View Related Products by Target Fas Receptor