Ethyl N-Boc-4-methylpiperidine-4-carboxylate

Names

[ Name ]:
Ethyl N-Boc-4-methylpiperidine-4-carboxylate

[Synonym ]:
1-BOC-4-METHYL-ISONIPECOTIC ACID ETHYL ESTER
N-tert-butoxycarbonyl-4-methylisonipecotic acid ethyl ester
4-methyl-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethvl ester
1-tert-Butyl 4-ethyl 4-methylpiperidine-1,4-dicarboxylate
Ethyl N-Boc-4-methylpiperidine-4-carboxylate
1-BOC-4-METHYLPIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER
Ethyl N-Boc-4-Methylpiperidine-4-Carboxylate
4-methyl piperidine-1,4-dicarboxylic acid-1-tert-butylester 4-ethyl ester
4-Methyl-1,4-piperidinedicarboxylic acid 1-(1,1-dimethylethyl) 4-ethyl ester
Ethyl 1-N-Boc-4-methyl-piperidine-carboxylate
ethyl N-t-butoxycarbonyl-4-methylpiperidine-4-carboxylate
O1-tert-butyl O4-ethyl 4-methylpiperidine-1,4-dicarboxylate
1-tert-butyl 4-ethyl 4-methylpiperidine-1,4-dicarboxylate
1-tert-Butoxycarbonyl-4-methylpiperidine-4-carboxylic acid ethyl ester

Chemical & Physical Properties

[ Density]:
1.0134

[ Boiling Point ]:
329.7ºC at 760mmHg

[ Molecular Formula ]:
C₁₄H₂₅NO₄

[ Molecular Weight ]:
271.35300

[ Flash Point ]:
110ºC

[ Exact Mass ]:
271.17800

[ PSA ]:
55.84000

[ LogP ]:
2.52620

[ Vapour Pressure ]:
0.000175mmHg at 25°C

[ Index of Refraction ]:
1.4554

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H315-H318-H335

[ Precautionary Statements ]:
P261-P280-P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
R25;R37/38;R41

[ Safety Phrases ]:
26-36/37/39-45

[ RIDADR ]:
UN 2810

[ Hazard Class ]:
6.1

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Facile synthesis of 4-substituted-4-aminopiperidine derivatives, the key building block of piperazine-based CCR5 antagonists.

Bioorg. Med. Chem. Lett. 14 , 3675, (2004)

4-Substituted-4-aminopiperidine is an interesting structural motif found in a number of bioactive compounds. An efficient and convenient method for the synthesis of 4-differently substituted-4-aminopi...