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PDE1-IN-2

Names

[ CAS No. ]:
1904611-63-7

[ Name ]:
PDE1-IN-2

[Synonym ]:
1,2,4-Triazolo[4,3-a]pyrazin-8(7H)-one, 6-bromo-7-(cyclopentylmethyl)-3-(tetrahydro-2H-pyran-4-yl)-
6-Bromo-7-(cyclopentylmethyl)-3-(tetrahydro-2H-pyran-4-yl)[1,2,4]triazolo[4,3-a]pyrazin-8(7H)-one

Biological Activity

[Description]:

PDE1-IN-2 is an inhibitor of PDE1 extracted from patent WO2016/55618 A1, example 31; has IC50 values of 6, 140 and 164 nM for PDE1C, PDE1B and PDE1A, respectvely.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)
Research Areas >> Neurological Disease

[References]

[1]. WO2016055618A1


[Related Small Molecules]

3-Isobutyl-1-methylxanthine | rolipram | PF-04957325 | AN-2728 | GLPG1690 | BAY-60-7550 | Icariin | Ibudilast | PF-8380 | TAK-063 | Dipyridamole | Cilostazol | GSK256066 | Cialis | Pentoxifylline

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
563.8±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C16H21BrN4O2

[ Molecular Weight ]:
381.267

[ Flash Point ]:
294.8±32.9 °C

[ Exact Mass ]:
380.084778

[ LogP ]:
1.94

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.738

[ Storage condition ]:
2-8℃

Related Compounds