(R)-2-Hydroxymethylpropanoic acid

Names

[ CAS No. ]:
1910-47-0

[ Name ]:
(R)-2-Hydroxymethylpropanoic acid

[Synonym ]:
R-b-Hydroxyisobutyrate
R-β-Hydroxyisobutyric acid
3-hydroxy-2-methylpropionate
D-b-Hydroxyisobutyrate
(2R)-3-Hydroxy-2-methylpropanoic acid
Propanoic acid, 3-hydroxy-2-methyl-, (2R)-
oxy-isobutyric acid
R-b-Hydroxyisobutyric acid
3-hydroxyisobutyric acid
2-hydroxymethylpropionic acid
(R)-3-Hydroxy-2-methylpropionic acid
(R)-2-Hydroxymethylpropanoic acid
(R)-3-Hydroxyisobutyric acid

Biological Activity

[Description]:

(R)-3-Hydroxyisobutyric acid is an intermediate in the pathways of l-valine and thymine and plays an important role in the diagnosis of the very rare inherited metabolic diseases 3-hydroxyisobutyric aciduria and methylmalonic semialdehyde dehydrogenase deficiency.

[Related Catalog]:

Natural Products >> Acids and Aldehydes

Research Areas >> Others

[Target]

Human Endogenous Metabolite

[References]

[1]. Podebrad F, et al. Stereodifferentiation of 3-hydroxyisobutyric- and 3-aminoisobutyric acid in human urine by enantioselective multidimensional capillary gas chromatography-mass spectrometry. Clin Chim Acta. 2000 Feb 25;292(1-2):93-105.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
252.9±23.0 °C at 760 mmHg

[ Molecular Formula ]:
C₄H₈O₃

[ Molecular Weight ]:
104.104

[ Flash Point ]:
121.0±19.1 °C

[ Exact Mass ]:
104.047340

[ PSA ]:
57.53000

[ LogP ]:
-1.14

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.455

Safety Information

[ HS Code ]:
2918199090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918199090

[ Summary ]:
2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%