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GGTI-2147

Names

[ CAS No. ]:
191102-87-1

[ Name ]:
GGTI-2147

[Synonym ]:
Methyl N-{4-[(1H-imidazol-5-ylmethyl)amino]-2-(1-naphthyl)benzoyl}-L-leucinate
methyl N-{4-[(1H-imidazol-4-ylmethyl)amino]-2-(naphthalen-1-yl)benzoyl}-L-leucinate
L-Leucine, N-[4-[(1H-imidazol-5-ylmethyl)amino]-2-(1-naphthalenyl)benzoyl]-, methyl ester

Biological Activity

[Description]:

GGTI-2147 is a potent GGTase I inhibitor. GGTI-2147 blocks geranyl-geranylation of Rap1A and reduces the activity of Rac1 (one of substrates for GGTI) and ameliorates the OGD/R-induced neuronal apoptosis.GGTI-2147 can be used for neurodevelopmental disorders research, such as autism, depression, and schizophrenia[1].

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS
Research Areas >> Neurological Disease

[References]

[1]. Shangfeng Gao, et al. Astrocyte GGTI-mediated Rac1 prenylation upregulates NF-κB expression and promotes neuronal apoptosis following hypoxia/ischemia. Neuropharmacology. 2016 Apr:103:44-56.  

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
710.6±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C28H30N4O3

[ Molecular Weight ]:
470.563

[ Flash Point ]:
383.5±32.9 °C

[ Exact Mass ]:
470.231781

[ LogP ]:
4.23

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.640

Related Compounds