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Propachlor

Names

[ CAS No. ]:
1918-16-7

[ Name ]:
Propachlor

[Synonym ]:
2-Chloro-N-isopropylacetanilide
Satecid
N-isopropyl-2-chloroacetanilide
2-Chloro-N-isopropyl-N-phenyl-acetamide
Niticid
N-isopropyl-N-phenyl-chloroacetamide
2-Chloro-N-isopropyl-N-phenylacetamide
Prolex
Propachlore
2-Chloro-N-(1-methylethyl)-N-phenylacetamide (9CI)
Nitacid
α-chloro-N-isopropylacetanilide
MFCD00078731
EINECS 217-638-2
Bexton
2-chloro-N-(1-methylethyl)-N-phenylacetamide
2-chloro-N-phenyl-N-(propan-2-yl)acetamide
n-isopropyl-a-chloroacetanilide
Bexton 4L
2-chloro-N-phenyl-N-propan-2-ylacetamide
Acetamide, 2-chloro-N-(1-methylethyl)-N-phenyl-
Ramrod
Propachlor

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
290.4±23.0 °C at 760 mmHg

[ Melting Point ]:
67-76°C

[ Molecular Formula ]:
C11H14ClNO

[ Molecular Weight ]:
211.688

[ Flash Point ]:
129.4±22.6 °C

[ Exact Mass ]:
211.076385

[ PSA ]:
20.31000

[ LogP ]:
2.28

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.551

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AE1575000
CHEMICAL NAME :
Acetanilide, 2-chloro-N-isopropyl-
CAS REGISTRY NUMBER :
1918-16-7
LAST UPDATED :
199806
DATA ITEMS CITED :
20
MOLECULAR FORMULA :
C11-H14-Cl-N-O
MOLECULAR WEIGHT :
211.71
WISWESSER LINE NOTATION :
G1VNR&Y1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
710 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1056 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
290 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
306 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
392 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
380 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - quail
DOSE/DURATION :
91 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - duck
DOSE/DURATION :
512 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3458 mg/kg/26W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1400 mg/kg/20D-I
TOXIC EFFECTS :
Liver - liver function tests impaired Blood - pigmented or nucleated red blood cells Biochemical - Metabolism (Intermediary) - other proteins
TYPE OF TEST :
Mutation test systems - not otherwise specified
TYPE OF TEST :
Sperm Morphology

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
10 mg/kg
REFERENCE :
CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK. (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974- Volume(issue)/page/year: 14(6),38,1980 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H317-H319-H410

[ Precautionary Statements ]:
P273-P280-P305 + P351 + P338-P501

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;N:Dangerousfortheenvironment;

[ Risk Phrases ]:
R22;R36;R43;R50/53

[ Safety Phrases ]:
S24-S37-S60-S61

[ RIDADR ]:
UN 2811

[ RTECS ]:
AE1575000

[ HS Code ]:
2924299014

Precursor & DownStream

Customs

[ HS Code ]: 2924299014

[ Summary ]:
2924299014 2-chloro-n-isopropyl-n-phenylacetamide。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%

Articles

Glutathione-dependent cytotoxicity of the chloroacetanilide herbicides alachlor, metolachlor, and propachlor in rat and human hepatoma-derived cultured cells.

Cell Biol. Toxicol. 15(5) , 325-32, (1999)

Alachlor, metolachlor, and propachlor are widely used chloroacetanilide herbicides. Their cytotoxicity in rat (Fa32) and human (Hep G2) hepatoma-derived cells was investigated, in connection with thei...

Kinetics and mechanism of propachlor reductive transformation through nucleophilic substitution by dithionite

Chemosphere 85(9) , 1438-43, (2011)

Highlights ► The reductive dechlorination of propachlor was efficiently achieved by dithionite. ► The transformation of propachlor initiated by dithionite follows second-order kinetics. ► Dechlorinati...

Characterization of glutathione conjugates of chloroacetanilide pesticides using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry and liquid chromatography/ion trap mass spectrometry.

Rapid Commun. Mass Spectrom. 21(24) , 4017-22, (2007)

Glutathione S-transferases (GSTs) isolated from maize were used to catalyze the conjugation of glutathione (GSH) with chloroacetanilide herbicides, producing stable conjugates that were structurally c...


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