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Carboxypeptidase G2 (CPG2) Inhibitor

Names

[ CAS No. ]:
192203-60-4

[ Name ]:
Carboxypeptidase G2 (CPG2) Inhibitor

[Synonym ]:
CS-0824
Carboxypeptidase G2 (CPG2) Inhibitor
L-Glutamic acid,N-[[(4-methoxyphenyl)thio]carbonyl]
Carboxypeptidase G2 (CPG2) Inhibitor||L-Glutamic acid,N-[[(4-methoxyphenyl)thio]carbonyl]

Biological Activity

[Description]:

Carboxypeptidase G2 (CPG2) Inhibitor is a novel Carboxypeptidase G2 (CPG2) Inhibitor, Antitumor agents.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Carboxypeptidase
Research Areas >> Cancer

[References]

[1]. Khan, Tariq H.; Eno-Amooquaye, Ebun A.; Searle, Frances et al. Novel Inhibitors of Carboxypeptidase G2 (CPG2): Potential Use in Antibody-Directed Enzyme Prodrug Therapy. Journal of Medicinal Chemistry (1999), 42(6), 951-956.

[2]. Friedlos F, Lehouritis P, Ogilvie L et al. Attenuated Salmonella targets prodrug activating enzyme carboxypeptidase G2 to mouse melanoma and human breast and colon carcinomas for effective suicide gene therapy. Clin Cancer Res. 2008 Jul 1;14(13):4259-66.

[3]. Schepelmann S, Ogilvie LM, Hedley D et al. Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2. Cancer Res. 2007 May 15;67(10):4949-55.

[4]. Schepelmann S, Hallenbeck P, Ogilvie LM et al. Systemic gene-directed enzyme prodrug therapy of hepatocellular carcinoma using a targeted adenovirus armed with carboxypeptidase G2. Cancer Res. 2005 Jun 15;65(12):5003-8.


[Related Small Molecules]

2-(Phosphonomethyl)pentanedioic acid | CPA inhibitor

Chemical & Physical Properties

[ Density]:
1.43

[ Molecular Formula ]:
C13H15NO6S

[ Molecular Weight ]:
313.32600

[ Exact Mass ]:
313.06200

[ PSA ]:
141.72000

[ LogP ]:
2.01930

Related Compounds