(5Z,8Z,14Z)-11,12-dihydroxyicosa-5,8,14-trienoic acid

Names

[ CAS No. ]:
192461-95-3

[ Name ]:
(5Z,8Z,14Z)-11,12-dihydroxyicosa-5,8,14-trienoic acid

Biological Activity

[Description]:

11,12-DiHETrE, an endogenous metabolite, is a Cytochrome P450 (P450) eicosanoid. 11,12-DiHETrE can be used for preterm labor research. 11,12-DiHETrE can be used as a single biomarker for differentiating NAFL (nonalcoholic fatty liver) from NASH (nonalcoholic steatohepatitis)[1][2].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[References]

[1]. Svenvik M, et al. Plasma oxylipin levels associated with preterm birth in preterm labor. Prostaglandins Leukot Essent Fatty Acids. 2021 Mar;166:102251.

[2]. Loomba R, et al. Polyunsaturated fatty acid metabolites as novel lipidomic biomarkers for noninvasive diagnosis of nonalcoholic steatohepatitis. J Lipid Res. 2015 Jan;56(1):185-92.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₃₄O₄

[ Molecular Weight ]:
338.48200

[ Exact Mass ]:
338.24600

[ PSA ]:
77.76000

[ LogP ]:
4.38230