G-9791

Names

[ CAS No. ]:
1926204-95-6

[ Name ]:
G-9791

Biological Activity

[Description]:

A potent and selective group I PAK (pan-PAK1/2/3) inhibitor with Ki of 0.95/2 nM for PAK1/2, respectively; displays 57-fold selectivity over Lck kinase; inhibits the phosphorylation of residue S298 of MEK1 in EBC1 cells with IC50 of 33 nM.

[References]

References 1. Rudolph J, et al. J Med Chem. 2016 Jun 9;59(11):5520-41. View Related Products by Target p21-activated Kinase (PAK)

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₂₆ClFN₆O₂

[ Molecular Weight ]:
508.98

Related Compounds

G-KG
G 476
G-6-P-Na2, Robison ester
G-744
G(Cbz)-acetic acid
G 28UCM
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine
4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide
N-[3-(Aminooxy)propyl]-N-butyl-1-butanamine