RWJ-49815

A potent bactericidal agent that inhibits the KinA autophosphorylation with IC50 of 1.6 uM; inhibits the autophosphorylation of kinase A of the KinA-Spo0F two-component signal transduction system in vitro; suppresses growth of MRSA, vancomycin-resistant Enterococcus faecium, and penicillin-resistant Streptococcus pneumoniae (MICs=1-2 ug/ml); exhibits reduced resistance emergence in a laboratory passage experiment compared with quinolone and ciprofloxacin.

References 1. Barrett JF, et al. Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5317-22. 2. Stephenson K, et al. J Biol Chem. 2000 Dec 8;275(49):38900-4. 3. Theodorou EC, et al. Cell Signal. 2011 Aug;23(8):1327-37. View Related Products by Target Bacterial