ZINC194100678

Names

[ CAS No. ]:
1995025-05-2

[ Name ]:
ZINC194100678

Biological Activity

[Description]:

ZINC194100678 is a potent PAK1 inhibitor with an IC50 value of 8.37 μM. ZINC194100678 can inhibit MDA-MB-231 cell proliferation. ZINC194100678 can be used for researching anticancer[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cytoskeleton >> PAK

Signaling Pathways >> Cell Cycle/DNA Damage >> PAK

[Target]

PAK1:8.37 μM (IC50)

[In Vitro]

ZINC194100678 (0-50 μM; 48 hours) exhibits potent antiproliferative activity with an IC50 value of 40.16 μM[1]. Cell Proliferation Assay Cell Line: MDA-MB-231[1] Concentration: 0-50 μM Incubation Time: 48 hours Result: Exhibited potent antiproliferative activity with an IC50 value of 40.16 μM.

[References]

[1]. Zhang J, et al. Design, synthesis and biological evaluation of 1H-pyrazolo [3,4-d]pyrimidine derivatives as PAK1 inhibitors that trigger apoptosis, ER stress and anti-migration effect in MDA-MB-231 cells. Eur J Med Chem. 2020;194:112220.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₁₃N₅O

[ Molecular Weight ]:
219.24

ZINC194100678

Names

Biological Activity

Chemical & Physical Properties

Related Compounds