HTH-01-091
Names
[ CAS No. ]:
2000209-42-5
[ Name ]:
HTH-01-091
Biological Activity
[Description]:
HTH-01-091 is a potent and selective, cell-permeable, ATP-competitive MELK inhibitor with biochemical IC50 of 10.5 nM; displays no significant activity for PIK3CA, mTOR, GSK3A and CDK7 (IC50>600 nM); exhibits substantially improved kinome selectivity in comparison with OTSSP167; induces MELK degradation, but demonstrates poor antiproliferative effects in basal-like breast cancer cell lines.
[References]
References 1. Huang HT, et al. Elife. 2017 Sep 19;6. pii: e26693. View Related Products by Target MELK
Chemical & Physical Properties
[ Molecular Formula ]:
C26H28Cl2N4O2
[ Molecular Weight ]:
499.436