Succinic acid-13C4

Names

[ CAS No. ]:
201595-67-7

[ Name ]:
Succinic acid-13C4

[Synonym ]:
Yantar-antitox-13C4
Dihydrofumaric Acid-13C4
Amber Acid-13C4
1,4-Butanedioic Acid-13C4
MFCD00145335
Butanedioic acid-13C4
Katasuccin-13C4
Wormwood Acid-13C4
Asuccin-13C4

Biological Activity

[Description]:

Succinic acid-13C4 is the 13C labeled Succinic acid[1]. Succinic acid is a potent and orally active anxiolytic agent. Succinic acid is an intermediate product of the tricarboxylic acid cycle. Succinic acid can be used as a precursor of many industrially important chemicals in food, chemical and pharmaceutical industries[2][3].

[Related Catalog]:

Research Areas >> Neurological Disease

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

[2]. Zhang YJ, et al. Optimization of succinic acid fermentation with Actinobacillus succinogenes by response surface methodology (RSM). J Zhejiang Univ Sci B. 2012 Feb;13(2):103-10.

[3]. A T JOHNS, et al. The production of propionic acid by decarboxylation of succinic acid in a bacterial fermentation. Biochem J. 194842(1):ii.

[4]. Si Wei Chen, Anxiolytic-like effect of succinic acid in mice. Life Sci. 2003 Nov 773(25):3257-64.

Chemical & Physical Properties

[ Density]:
1.408g/cm3

[ Boiling Point ]:
235ºC

[ Melting Point ]:
187-190ºC(lit.)

[ Molecular Formula ]:
C₄H₆O₄

[ Molecular Weight ]:
122.05900

[ Exact Mass ]:
122.04000

[ PSA ]:
74.60000

[ Index of Refraction ]:
1.477

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H315-H318-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

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