AZ 1729

Names

[ CAS No. ]:
2016864-46-1

[ Name ]:
AZ 1729

Biological Activity

[Description]:

AZ1729 is a novel direct, positive allosteric modulator of fatty acid receptor FFA2 (pEC50=6.9), selectively activates Gi signaling but lacks the capacity to activate FFA2 Gq/G11-mediated signaling pathways; produces stimulation of [35S]GTPγS binding with pEC50 7.23, inhibits β-adrenoreceptor agonist-promoted lipolysis in primary mouse adipocytes and promotes chemotaxis of isolated human neutrophils.

[References]

References 1. Bolognini D, et al. J Biol Chem. 2016 Sep 2;291(36):18915-31. View Related Products by Target Free Fatty Acid Receptor (FFAR)

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₆FN₅OS

[ Molecular Weight ]:
369.418

Related Compounds

AZ 3451
AZ-4217
AZ-32
AZ 6102
AZ 4800
AZ-7550 Mesylate
4-((4-(Difluoromethoxy)phenyl)amino)-4-oxo-2-((pyridin-3-ylmethyl)amino)butanoic acid
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
2-(6-methyl-1-benzofuran-3-yl)-N-[5-(propylsulfanyl)-1,3,4-thiadiazol-2-yl]acetamide
2-[(5-Chloro-2-nitrophenyl)sulfanyl]benzoic acid
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
2-chloro-N-(1H-indazol-5-yl)benzenesulfonamide
4-(S-Acetylthiomethyl)benzaldehyde
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(3-Fluorophenyl)(phenyl)sulfane