(R)-IDO/TDO-IN-1

Names

[ CAS No. ]:
2033173-00-9

[ Name ]:
(R)-IDO/TDO-IN-1

Biological Activity

[Description]:

(R)-IDO/TDO-IN-1 (compound 25) is an indoleamine-2,3-dioxygenase (IDO) inhibitor, with good pharmacokinetic properties. (R)-IDO/TDO-IN-1 exhibits anti-tumor activity in MC38 xenograft model. (R)-IDO/TDO-IN-1 shows synergistic effect with anti-PD-1 monoclonal antibody (SHR-1210)[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Indoleamine 2,3-Dioxygenase (IDO)
Research Areas >> Others

[References]

[1]. Tu W, Yang F, Xu G, Chi J, Liu Z, Peng W, Hu B, Zhang L, Wan H, Yu N, Jin F, Hu Q, Zhang L, He F, Tao W. Discovery of Imidazoisoindole Derivatives as Highly Potent and Orally Active Indoleamine-2,3-dioxygenase Inhibitors. ACS Med Chem Lett. 2019 Jun 3;10(6):949-953.  

Chemical & Physical Properties

[ Molecular Formula ]:
C25H24FN5

[ Molecular Weight ]:
413.49

Related Compounds