4H-pyrido[3,2-b][1,4]oxazin-3-one

Names

[ CAS No. ]:
20348-09-8

[ Name ]:
4H-pyrido[3,2-b][1,4]oxazin-3-one

[Synonym ]:
2H-Pyrido[3,2-b]-1,4-oxazin-3(4H)-one
2H-Pyrido[4,3-b]-1,4-oxazin-3-(4H)-one
2H-Pyrido[3,2-b][1,4]oxazin-3(4H)-one
pyridoboxazinone
EINECS 243-751-1
MFCD00006697

Chemical & Physical Properties

[ Density]:
1.328g/cm3

[ Boiling Point ]:
384.159ºC at 760 mmHg

[ Melting Point ]:
204-206 °C(lit.)

[ Molecular Formula ]:
C₇H₆N₂O₂

[ Molecular Weight ]:
150.13500

[ Exact Mass ]:
150.04300

[ PSA ]:
51.22000

[ LogP ]:
0.55050

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.568

MSDS

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Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2934999090

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Synthesis and biological evaluation of oxadiazole derivatives as inhibitors of soluble guanylyl cyclase.

Bioorg. Med. Chem. 18(3) , 1288-96, (2010)

Soluble guanylyl cyclase (sGC) is an ubiquitously expressed enzyme that generates the second messenger cGMP and hence, leads to a number of physiological responses including vasodilation, inhibition o...