4-Hydroxychalcone

Names

[ CAS No. ]:
20426-12-4

[ Name ]:
4-Hydroxychalcone

[Synonym ]:
4-HYDROXYBENZYLIDENEACETOPHENONE
2-(4-Hydroxybenzylidene)acetophenone
2-(4-Hydroxybenzal)acetophenone
4-HYDROXYCHALCONE
MFCD00016488
HYDROXYCHALCONE,4
BENZYLIDENE-4-HYDROXYACETOPHENONE

Biological Activity

[Description]:

4-Hydroxychalcone is a chalcone metabolite with anti-angiogenic and anti-inflammatory activities. 4-Hydroxychalcone suppresses angiogenesis by suppression of growth factor pathway with no signs of cytotoxicity[1]. 4-Hydroxychalcone inhibits TNF-α induced NF-κB pathway activation and activates BMP signaling, reduces resistant hypertension (RH) by attenuating hyperaldosteronism and renal injury in mice[2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Research Areas >> Inflammation/Immunology

[Target]

NF-κB[2]

[References]

[1]. Varinska L, et al. Anti-angiogenic activity of the flavonoid precursor 4-hydroxychalcone. Eur J Pharmacol. 2012 Sep 15;691(1-3):125-33.

[2]. Qu Q, et al. 4-Hydroxychalcone attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice. Biomed Res Int. 2014;2014:603415.

Chemical & Physical Properties

[ Melting Point ]:
180-184 °C

[ Molecular Formula ]:
C₁₅H₁₂O₂

[ Molecular Weight ]:
224.25500

[ Exact Mass ]:
224.08400

[ PSA ]:
37.30000

[ LogP ]:
3.28830

MSDS

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Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38:Irritating to eyes, respiratory system and skin .

[ Safety Phrases ]:
S37/39-S26

[ RIDADR ]:
3077.0

[ RTECS ]:
UD1675000

[ Hazard Class ]:
9.0

[ HS Code ]:
2914501900

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914501900

[ Summary ]:
2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%