ABX-1431 hydrochloride
Names
[ CAS No. ]:
2043074-64-0
[ Name ]:
ABX-1431 hydrochloride
Biological Activity
[Description]:
ABX-1431 (ABX1431) is a highly potent, selective, orally available, CNS-penetrant monoacylglycerol lipase (MGLL) with IC50 of 14 nM (hMGLL); displays 23-fold selectivity for MGLL versus ABHD6 and CES1c, as well as exquisite selectivity of against other members of the serine hydrolase class; inhibits MGLL activity in rodent brain (ED50=0.5-1.4 mg/kg), increases brain 2-AG concentrations, and suppresses pain behavior in the rat formalin pain model. Pain Phase 1 Clinical
[References]
References 1. Cisar JS, et al. J Med Chem. 2018 Aug 1. doi: 10.1021/acs.jmedchem.8b00951. View Related Products by Target Monoacylglycerol Lipase (MAGL) Pain
Chemical & Physical Properties
[ Molecular Formula ]:
C20H23ClF9N3O2
[ Molecular Weight ]:
543.859