Mcl1-IN-26

Names

[ CAS No. ]:
2056238-04-9

[ Name ]:
Mcl1-IN-26

Biological Activity

[Description]:

A novel potent, selective Mcl-1 inhibitor with IC50 of <3 nM in FRET assays; displays >1,000-fold selectivity over Bcl-2 and Bcl-xL; induces cleaved caspase-3 in MV4-11 cells with IC50 of 3.78 uM.

[References]

References 1. Johannes JW, et al. ACS Med Chem Lett. 2016 Dec 27;8(2):239-244. View Related Products by Target Bcl-2

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₅H₅₂ClN₅O₆S

[ Molecular Weight ]:
826.45

Related Compounds

Mcl1-IN-4
Mcl1-IN-3
Mcl1-IN-2
Mcl1-IN-9
Mcl1-IN-1
Mcl1-IN-11
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
5-Cyclopropoxy-4-isopropoxy-N,N-dimethylpyridin-2-amine
N-[2-(6-fluoro-2-methyl-4-oxoquinazolin-3(4H)-yl)ethyl]-1H-indole-4-carboxamide
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
O-Desisopropyl-O-methyl Bisoprolol-d7 Hemifumarate
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
5-[(3-Ethoxy-5-iodo-4-methoxyphenyl)methylene]-3-ethyl-2-[(4-methoxyphenyl)imino]-4-thiazolidinone
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide